Coyote vs. Acme does not match the perfection of Who Framed Roger Rabbit?, according to HBL, but it still succeeds on its own terms. The review highlights polished filmmaking that brings together heart, social critique and humour in a way that works.

Rather than feeling like a simple nod to classic animation and slapstick, the film is presented as a well-built whole with its own identity. HBL sums up the verdict bluntly: it is simply a very good film.